The laboratory is studying small molecules that selectively inhibit the components of RAS-RAF-MEK-ERK and PI3K-AKT-mTOR pathways. These compounds are ... are selectively dependent for growth on the ...

The results showed that cordycepin significantly inhibited growth factor signaling in multiple cell lines, particularly through the MEK/ERK and PI3K/AKT/mTOR pathways. This inhibition was observed ...