Use of angiotensin-converting-enzyme inhibitors has been associated with an increased risk of developing the chronic pain condition, which suggests possible roles for substance P and bradykinin in ...

Although both groups of drugs lower blood pressure, studies of the ACE inhibitor perindopril have revealed preservation of beneficial vascular and endothelial effects mediated by bradykinin and ...

As angiotensin-II is subtracted from this hemodynamic equation, there can be a precipitous fall in BP, which is only worsened by the actions of the vasodilator bradykinin. ACE inhibitor-related ...

5) and to study its enzymatic properties, and soon thereafter, Miguel Ondetti and I began a fruitful collaborative effort to discover or design potent and specific inhibitors of ACE. The modern ...