Yet, with this intensified interest in AAV therapies comes the need to scale-up viral production methods. As such, it’s imperative that successful viral production produce high titers that is ...

With their increasing adoption, precise tools are vital for quantifying AAV capsid titers and detecting anti-AAV antibodies to ensure the safety, efficacy and proper dosing of therapies. This ...

While asymptomatic, these infections trigger the generation of neutralizing anti-AAV antibodies that can, even at low titers, substantially impair the therapeutic effect of an AAV vector.

providing higher workflow flexibility and a more detailed assessment of AAV viral titer and capsid integrity. Utilizing Droplet Digital ™ PCR (ddPCR), Bio-Rad Laboratories developed a new ...

and capsid titer. Fig 1. The Vericheck ddPCR Empty-Full Capsid Kit method. DNase treatment removes external DNA. Probes then specifically bind to AAV capsids. Oligos on these probes ligate ...

Sartorius’ AAVX biosensor was developed to enable rapid, real-time and high-throughput measurement of AAV capsid titer in samples across the AAV bioprocess workflow, facilitating quick process ...

The Vericheck ddPCR Empty-Full Capsid Kit was designed to help scientists and AAV developers accurately measure both the genome titer and empty-full ratios in their samples. In the world of AAV ...

Users can dig into the adenovirus vector (AdV) or AAV to get the total capsid titer and empty/full ratio or rack up payload concentration and size data on any nanoparticle simultaneously. Nail down ...