For central nervous system (CNS) applications, attempts are being made to deliver AAV gene therapy directly to the brain parenchyma or the cerebrospinal fluid (CSF) space by intra-cisterna magna ...

They also demonstrated that using AAV to deliver both NeuroD1 and Dlx2, another transcription factor, regenerated GABAergic neurons in a mouse model of Huntington’s disease, significantly ...

Finally, AAV transduction was performed by transducing ... can trigger dopaminergic neuron degeneration and the disruption of other neurons’ dendrites in a concentration-dependent manner ...

Single AAV Systems for HDR-Mediated Genome Editing in Vivo Dual AAV Systems for HDR-Mediated Genome Editing in Vivo ...

Single AAV Systems for HDR-Mediated Genome Editing in Vivo Dual AAV Systems for HDR-Mediated Genome Editing in Vivo ...

Following treatment, the AAV-Navβ1 vector successfully expressed ... improving cortical neuron excitability. However, despite the significant increase in survival, treated mice failed to gain ...