脂肪组织与中枢神经系统之间存在复杂的通信机制，以维持全身能量稳态。传统观点认为，脂肪组织通过分泌循环激素向大脑传递代谢状态信息，而大脑则通过交感神经输出调节脂肪细胞功能。背根神经节（DRG）的感觉神经元也被证实支配脂肪组织，但其生理重要性因缺乏特异性 ...

Somatic gene transfer with vectors such as adeno-associated virus (AAV) can overcome these limitations. ReGenX's AAV Vector Technology gives extremely efficient and stable gene expression in ...

The SuM. Injection of Cre-dependent AAV in SuM-Cre mice resulted in SuM-restricted eYFP (green) expression and strong terminal labeling in the DG and CA2 of the hippocampus. Scale bar, 1 mm ...

For central nervous system (CNS) applications, attempts are being made to deliver AAV gene therapy directly to the brain parenchyma or the cerebrospinal fluid (CSF) space by intra-cisterna magna ...

and then sequenced the genomes of the viruses that successfully infected the Cre-expressing cells. He then used these recovered sequences to generate a second library for another round of testing.