The SuM. Injection of Cre-dependent AAV in SuM-Cre mice resulted in SuM-restricted eYFP (green) expression and strong terminal labeling in the DG and CA2 of the hippocampus. Scale bar, 1 mm ...
Existing gene therapies have primarily used a small number of naturally occurring AAV vectors limited by low delivery efficiency as well as problems with pre-existing immunity and manufacturability.
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