R.J. Samulski, M. Sally and N. Muzyczka provide a comprehensive review on recombinant AAV biology. Cellular uptake of AAV virions and use of heparan sulfate as a receptor for AAV are discussed.

Previous efforts to circumvent the problem of the size limitation imposed by the AAV vector have focused mainly on altering the candidate genes into ‘mini-expression cassettes’ suitable for ...

Then their infectious genetic material is replaced with the therapeutic genetic material, and they are administered to the ...

AAV peptide display libraries allow for the generation of novel variants capable of high-level transduction. We previously described an AAV peptide display library combined with a sensitive ...

Retinal ganglion cells are neurons tasked with relaying visual information from the retina to the brain Lenadogene nolparvovec, an adeno-associated virus (AAV)-based gene therapy, was developed to ...